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Hyperglycemic conditions also induce TNF expression in cardiomyocytes, which alters DNMT activity and promotes methylation of the SERCA2a gene promoter, leading to reduced SERCA2a expression, calcium overload, and subsequent diastolic heart failure [121]

however, some degree of hemolysis persists in post-splenectomy HE patients that indicates an incomplete response to splenectomy [8]

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Dosimetric modulation of the delivered beams according to the prescription plan shows optimistic clinical results, particularly in locally advanced tumors [19]